Informações que descrevem a caracterização de materiais, tamanho de partícula, propriedades de superfície, porosidade e estrutura de poros são essenciais para muitas tecnologias e indústrias. O potencial de aplicação dessas técnicas de caracterização, derivado de uma diversidade incomensurável de materiais e seus usos, pode ser ilimitado.
As physical characterization of pharmaceuticals becomes more of a focus, analytical techniques must be able to provide data that is representative of the materials being analyzed. Companies are implementing Quality by Design (QbD) and Process Analytical Technologies (PAT) initiatives to ensure robustness of formulas, processes, and products. Lyophilized products have key areas where these initiatives can play roles in product and process knowledge. Measurement of the surface area of lyophilized cakes provides valuable information on process capability and product consistency. BET surface area analysis of lyophilized products currently requires manipulation of the cake prior to testing to introduce the sample into the instrument sample tubes. This type of sample preparation technique for BET surface area testing may introduce error resulting in the lack of repeatability and robustness of the analysis and possible misrepresentation of the true surface area of the sample. Also, since manipulation is destructive to the sample, no further testing can be performed.
Measuring asphalt density per ASTM Test Method D70-09 requires the use of a glass pycnometer and very tedious analysis conditions. Using this ASTM method as a guide, the density of asphalt is measured using an AccuPyc II TEC and 3.3-cc disposable aluminum cups. The density results of four different asphalt samples using the AccuPyc are compared to results obtained by a third party using the ASTM glass pycnometer method. Results from the two methods ranged from a 0.003% to 0.026% difference.
A degas study was conducted to determine the effectiveness of flow versus vacuum degas. An amorphous silica-alumina and a microporous zeolite were prepared by both techniques and then nitrogen isotherms were collected for both materials. The resulting isotherms established equivalence between vacuum versus flow degas.